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Abstract #3957

31P Magnetic Resonance Fingerprinting Method for Efficient Measurement of Creatine Kinase Mediated High Energy Phosphate Metabolism

Charlie Yi Wang1, Yuchi Liu1, Shuying Huang1, Mark Alan Griswold1,2, and Xin Yu1,2

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States

We propose a novel 31P Creatine Kinase encoding Magnetic Resonance Fingerprinting method (CK-MRF) to efficiently measure high energy phosphate metabolism through creatine kinase (CK). Measurement reproducibility of CK rate constant (kf,CK) using CK-MRF was compared with both conventional 31P saturation transfer method, and Four Angle Saturation Transfer method in rat hind limb. CK-MRF measurement showed comparable or superior reproducibility using 20 s experiment time compared to 160 s experiment time of either comparison method. Changes in kf,CK following Ischemia/Reperfusion (IR) were also measured.

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