Abstract #3957

31P Magnetic Resonance Fingerprinting Method for Efficient Measurement of Creatine Kinase Mediated High Energy Phosphate Metabolism

Charlie Yi Wang¹, Yuchi Liu¹, Shuying Huang¹, Mark Alan Griswold^1,2, and Xin Yu^1,2

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, Case Western Reserve University, Cleveland, OH, United States

We propose a novel ³¹P Creatine Kinase encoding Magnetic Resonance Fingerprinting method (CK-MRF) to efficiently measure high energy phosphate metabolism through creatine kinase (CK). Measurement reproducibility of CK rate constant (k_f,CK) using CK-MRF was compared with both conventional ³¹P saturation transfer method, and Four Angle Saturation Transfer method in rat hind limb. CK-MRF measurement showed comparable or superior reproducibility using 20 s experiment time compared to 160 s experiment time of either comparison method. Changes in k_f,CK following Ischemia/Reperfusion (IR) were also measured.

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