Abstract #3960

Measurement of ATP Synthesis in Human Brain by 31P Localized Band Inversion Transfer at 7T

Jimin Ren¹, A. Dean Sherry¹, and Craig R. Malloy¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Despite recent advances in measuring ATP energy metabolism using 31P magnetization transfer, there is still a lack of localized techniques capable of assessing the regional ATP synthesis. The importance of measuring regional ATP rates and fluxes in the human brain is highlighted by the heterogeneity in normal brain functions and also in many cerebral metabolic abnormalities. In this study, we demonstrate that, by combining wide-band inversion transfer with image selected in vivo spectroscopy (ISIS), quantitative information regarding ATP synthesis reaction Pi ==> γ-ATP can be obtained from the localized regions in the human brain.

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