Abstract #3961

7T allows correct measurement of PDE in the human liver without decoupling

Lucian A. B. Purvis¹, William T. Clarke¹, Michael Pavlides¹, Matthew D. Robson¹, and Christopher T. Rodgers¹

¹OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

Phosphomonoesters (PME) and phosphodiesters (PDE) are emerging biomarkers in cirrhosis and fatty liver disease. In this study, phosphorus (³¹P) liver metabolite concentrations were quantified at 7T for 10 healthy volunteers using a 28 minute, 3D UTE-CSI sequence and an endogenous 2.5mM ATP reference. The inorganic phosphate concentration was 1.95 ± 0.18mM (1.25-2.43mM in the literature). Summing individual ester peaks, the total PME and PDE concentrations were 1.90 ± 0.29mM (cf. 1.98-3.89mM) and 4.31 ± 0.80mM (cf. 8.01-11.40mM). We attribute this apparent reduction in PDE to a broadening of the underlying phospholipid bilayer resonance and the increased spectral resolution at 7T.

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