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Abstract #3961

7T allows correct measurement of PDE in the human liver without decoupling

Lucian A. B. Purvis1, William T. Clarke1, Michael Pavlides1, Matthew D. Robson1, and Christopher T. Rodgers1

1OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

Phosphomonoesters (PME) and phosphodiesters (PDE) are emerging biomarkers in cirrhosis and fatty liver disease. In this study, phosphorus (31P) liver metabolite concentrations were quantified at 7T for 10 healthy volunteers using a 28 minute, 3D UTE-CSI sequence and an endogenous 2.5mM ATP reference. The inorganic phosphate concentration was 1.95 ± 0.18mM (1.25-2.43mM in the literature). Summing individual ester peaks, the total PME and PDE concentrations were 1.90 ± 0.29mM (cf. 1.98-3.89mM) and 4.31 ± 0.80mM (cf. 8.01-11.40mM). We attribute this apparent reduction in PDE to a broadening of the underlying phospholipid bilayer resonance and the increased spectral resolution at 7T.

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