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Abstract #3962

Simultaneous Assessment of Abnormal Glycolysis and Oxidative Metabolisms in Brain Tumor using In Vivo Deuterium MRS Imaging

Ming Lu1, Xiao-Hong Zhu1, Yi Zhang1, Walter Low2, and Wei Chen1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Neurosurgery, University of Minnesota, Minneapolis, MN, United States

Recently, we developed a novel 3D-Deuterium MR (DMR) approach able to simultaneously image glucose consumption rate and TCA cycle flux in rat brain at ultrahigh field. To evaluate its sensitivity in detecting altered metabolism, in this study, we acquired localized DMR spectra in rat brains with gliosarcoma following a brief infusion of deuterated glucose at 16.4 T. We observed accelerated glucose consumption and lactate accumulation accompany with decreased glutamate/glutamine turnover in brain regions with tumor. This pilot study demonstrates the feasibility of the in vivo DMR imaging approach for investigating abnormal glucose metabolism in brain tumor at ultrahigh field.

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