Abstract #3966

Iterative Approach for Partial Volume Corrected T2* Determination in 17O-MRI

Sebastian C. Niesporek¹, Reiner Umathum¹, Thomas M. Fiedler¹, and Armin M. Nagel^1,2

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany

The energy balance of a cell is closely connected to in-vivo H₂¹⁷O-concentration which also is the turnover product of oxidative phosphorylation. ¹⁷O-MRI during inhalation of ¹⁷O₂ enables localized mapping of cerebral metabolic rate of oxygen consumption (CMRO₂). Larger voxel sizes due to a low MR-sensitivity and short relaxation times induce partial volume effects which reduce quantification accuracy. For accurate signal correction exact T₂^*-values are essential. A partial volume correction algorithm for improved T₂^*-determination where T₂^*-values are adapted iteratively is presented. Consistent results to simulations were obtained for phantom and in-vivo data. The iteratively corrected in-vivo T₂^*-values were used for improved ¹⁷O-MRI-signal quantification.

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