Abstract #3965

Evaluation of High Temporal and Spatial Resolution 17O-MRI

Sebastian C. Niesporek¹, Reiner Umathum¹, Thomas M. Fiedler¹, and Armin M. Nagel^1,2

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany

Functional information of cell and tissue viability can be obtained via dynamic ¹⁷O-MRI. The quantification of H₂¹⁷O-concentration as a turnover product of oxidative phosphorylation in combination with ¹⁷O₂-inhalation enables mapping of the cerebral metabolic rate of oxygen consumption (CMRO₂). Due to low MR-sensitivity of the ¹⁷O-nucleus, spatial as well as temporal resolution is limited. Induced partial volume effects hinder accurate and stable signal quantification which is essential for dynamic studies. High resolution ¹⁷O-data with (4.5mm)³ was acquired with a Golden Angle acquisition scheme which allowed reconstruction of arbitrary time-frames. A partial volume correction algorithm was applied to test correction capability of data of different temporal resolution.

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