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Abstract #3965

Evaluation of High Temporal and Spatial Resolution 17O-MRI

Sebastian C. Niesporek1, Reiner Umathum1, Thomas M. Fiedler1, and Armin M. Nagel1,2

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany

Functional information of cell and tissue viability can be obtained via dynamic 17O-MRI. The quantification of H217O-concentration as a turnover product of oxidative phosphorylation in combination with 17O2-inhalation enables mapping of the cerebral metabolic rate of oxygen consumption (CMRO2). Due to low MR-sensitivity of the 17O-nucleus, spatial as well as temporal resolution is limited. Induced partial volume effects hinder accurate and stable signal quantification which is essential for dynamic studies. High resolution 17O-data with (4.5mm)3 was acquired with a Golden Angle acquisition scheme which allowed reconstruction of arbitrary time-frames. A partial volume correction algorithm was applied to test correction capability of data of different temporal resolution.

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