Abstract #3964

Initial investigation of glucose metabolism in mouse brain using enriched 17O-glucose and dynamic 17O-MRS

Robert Borowiak^1,2, Wilfried Reichardt^1,2, Dmitry Kurzhunov¹, Christian Schuch³, Jochen Leupold¹, Thomas Lange¹, Marco Reisert¹, Axel Krafft^1,2, Elmar Fischer¹, and Michael Bock¹

¹University Medical Center Freiburg, Dept. of Radiology - Medical Physics, Freiburg, Germany, ²German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, ³NUKEM Isotopes Imaging GmbH, Alzenau, Germany

In this work, we demonstrate the feasibility of monitoring glucose uptake in mouse brain using direct ¹⁷O-MRS at 9.4 Tesla for the first time. Time-resolved ¹⁷O-MRS spectra (temporal resolution: 42 s) are acquired in vivo after injection of D-glucose with ¹⁷O-labeled hydroxyl groups. The cerebral rate of glucose metabolism CMR_Glc is estimated using a pharmacokinetic model in an anesthetized (1.25% isoflurane) mouse to 0.43 ± 0.21 µmol/g/min, which is of the same order of magnitude as reported by ¹⁸F-FDG PET.

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