Abstract #3971

Towards direct detection of natural abundance glycogen C2-C6 resonances by localized 13C MRS at 7T.

Eulalia Serés Roig^1,2, Lijing Xin³, and Rolf Gruetter^4,5

¹Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Image Guided Interventions Laboratory, Radiology Department, University of Geneva (UNIGE), Geneva, Switzerland, ³Centre d'Imagerie Biomédicale - Animal and Imaging Technology (CIBM-AIT), Lausanne, Switzerland, ⁴Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland

Glycogen is the main energy store in the human body, while its concentration is particularly abundant in muscle tissue. In vivo ¹³C MRS is unique for investigating glycogen metabolism, as it allows the non-invasive measurement of natural abundance glycogen C₁ resonance in the human muscle. However, spatial localization is desirable to detect glycogen C₂-C₆ resonances due to their overlap with the glycerol C₂and C₁, C₃ resonances. In this study, we designed a pulse-acquire sequence for localized ¹³C MRS using ISIS-1D and OVS schemes. The localization performance of the sequence was validated in vitro and in vivo in human muscle at 7T.

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