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Abstract #3971

Towards direct detection of natural abundance glycogen C2-C6 resonances by localized 13C MRS at 7T.

Eulalia Serés Roig1,2, Lijing Xin3, and Rolf Gruetter4,5

1Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Image Guided Interventions Laboratory, Radiology Department, University of Geneva (UNIGE), Geneva, Switzerland, 3Centre d'Imagerie Biomédicale - Animal and Imaging Technology (CIBM-AIT), Lausanne, Switzerland, 4Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, 5Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland

Glycogen is the main energy store in the human body, while its concentration is particularly abundant in muscle tissue. In vivo 13C MRS is unique for investigating glycogen metabolism, as it allows the non-invasive measurement of natural abundance glycogen C1 resonance in the human muscle. However, spatial localization is desirable to detect glycogen C2-C6 resonances due to their overlap with the glycerol C2 and C1, C3 resonances. In this study, we designed a pulse-acquire sequence for localized 13C MRS using ISIS-1D and OVS schemes. The localization performance of the sequence was validated in vitro and in vivo in human muscle at 7T.

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