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Abstract #3972

Comparison of in vivo potassium, chloride and sodium TQ effects at 21.1 T

Victor Schepkin1, Andreas Neubauer2, Armin Nagel3, and Thomas Budinger4

1NHMFL/FSU, Tallahassee, FL, United States, 2University of Heidelberg, Mannheim, Germany, 3German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Lawrence Berkeley National Laboratory/ UCB, Berkeley, CA, United States

A comparison of the TQ MR signals without filtration from three in vivo ions was performed in a rat head at 21.1 T using a time proportional phase increment. A strong and competitive binding of potassium relative to sodium was demonstrated and confirmed using agarose samples. The TQ signal from in vivo chloride was the lowest. Our results support a model that normal cells have similar ion binding in intracellular and extracellular spaces. Visualization of TQ magnetization was demonstrated using matching angular dependence of spherical harmonics and corresponding irreducible tensors.

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