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Abstract #3973

Does Tempol enter the brain with an unpaired electron?

Miho C Emoto1, Hideo Sato-Akaba2, and Hirotada G Fujii1

1Center for Medical Education, Sapporo Medical University, Sapporo, Japan, 2Osaka University, Osaka, Japan

Nitroxides have unique biochemical properties, and thus they have been used for many biomedical applications. However, although piperidine nitroxide (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl: Tempol) has been presently tested in clinical trials, details concerning the distribution and kinetics of Tempol in vivo have not been thoroughly studied. In particular, it is not clear whether Tempol enters the brain as paramagnetic materials with an unpaired electron. To examine this matter, electron paramagnetic resonance (EPR) imaging study of mouse brains was conducted using a modified EPR imager. The obtained EPR images clearly showed that Tempol could enter the brain with an unpaired electron.

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