Abstract #3983

Model-based fitting of in vivo 129Xe spectra in mice reveals five robust dissolved-phase peaks

Rohan S. Virgincar¹, Scott H. Robertson², Simone Degan³, Geoffry Schrank⁴, Mu He⁵, John Nouls⁴, and Bastiaan Driehuys⁴

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³Center for Molecular and Biomolecular Imaging, Duke University, Durham, NC, United States, ⁴Radiology, Duke University, Durham, NC, United States, ⁵Electrical and Computer Engineering, Duke University, Durham, NC, United States

Inhaled ¹²⁹Xe exhibits chemical shifts which carry useful information about the underlying physiology. However, their resonant frequencies have been reported with a variability of 2-3 ppm likely attributable to using simplistic peak finding methods and inconsistent reference frequencies. In this work, we use robust non-linear curve fitting of the complex dissolved-phase spectrum in mice to identify resonances, and report shifts relative to an accurate reference frequency. At short ¹²⁹Xe replenishment times curve fitting identified two peaks at 197.4±0.9 and 193.0±0.7 ppm, but as replenishment time was increased, five distinct peaks became apparent at 198.4±0.4, 195.5±0.4, 193.9±0.2, 191.3±0.2, and 190.7±0.3 ppm.

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