Abstract #3984

Dynamic 1H MRS study of water T2* and water concentration contributions to water signal intensity changes in premotor cortex of the norm and in early stage schizophrenia during hemodynamic response to a single stimulus.

Svetlana Sergeevna Batova¹, Andrei Valerievich Manzhurtsev², Maxim Vadimovich Ublinskii^2,3, Irina Sergeevna Lebedeva⁴, Tolibjon Abdullaevich Akhadov³, Petr Evgenevich Menshchikov⁵, and Natalia Alexandrovna Semenova^2,3,5

¹Lomonosov Moscow State University, Moscow, Russian Federation, ²Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russian Federation, ³Radiology, Scientific Research Institute of Children's Emergent Surgery and Trauma, Moscow, Russian Federation, ⁴Scientific Centre of Mental Health, Moscow, Russian Federation, ⁵Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russian Federation

Using dynamic ¹H MRS we have separated T2* and water concentration contributions to changes of MRS detectable water signal in motor cortex after activation by a single short stimulus. We revealed effects of schizophrenia on both parameters in the period of hemodynamic response to stimulation. Decreased changes of T2* and water concentration in schizophrenia might reflect a lower vasodilation caused by a single short stimulus.

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