Abstract #3985

Assessment of the glutamatergic activity changes induced by Schizophrenia on rat model: A In Vivo Proton Magnetic Resonance Spectroscopy (¹H MRS) Study at 9.4 T

Chi-Hyeon Yoo^1,2, Do-Wan Lee¹, Kyu-Ho Song¹, Song-I Lim^1,2, Dong-Cheol Woo², and Bo-Young Choe¹

¹Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, ²Asan Institute for Life Science, Asan Medical Center, Seoul, Korea, Republic of

To investigate schizophrenia (SZ)-induced effects in the glutamatergic activity on prefrontal cortex of rat, we used proton magnetic resonance spectroscopy (¹H MRS) to estimate the concentration of glutamate (Glu) and glutamine (Gln). With a short echo time (TE) and 9.4 T of our study, Glu, Gln and glutamate-complex (Glx) were reliably quantified with a low Cramer-Raw low bound (CRLB) value, and Glu, Glx showed significant increase. As our results the SZ-induced change in the glutamatergic activity can be reliably detected by ¹H MRS.

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