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Abstract #3985

Assessment of the glutamatergic activity changes induced by Schizophrenia on rat model: A In Vivo Proton Magnetic Resonance Spectroscopy (¹H MRS) Study at 9.4 T

Chi-Hyeon Yoo1,2, Do-Wan Lee1, Kyu-Ho Song1, Song-I Lim1,2, Dong-Cheol Woo2, and Bo-Young Choe1

1Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, 2Asan Institute for Life Science, Asan Medical Center, Seoul, Korea, Republic of

To investigate schizophrenia (SZ)-induced effects in the glutamatergic activity on prefrontal cortex of rat, we used proton magnetic resonance spectroscopy (¹H MRS) to estimate the concentration of glutamate (Glu) and glutamine (Gln). With a short echo time (TE) and 9.4 T of our study, Glu, Gln and glutamate-complex (Glx) were reliably quantified with a low Cramer-Raw low bound (CRLB) value, and Glu, Glx showed significant increase. As our results the SZ-induced change in the glutamatergic activity can be reliably detected by ¹H MRS.

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