Abstract #3987

The Influence of Varenicline on Repeated Nicotine-Induced Rats: In Vivo Proton Magnetic Resonance Spectroscopy at 9.4T

Song-I Lim^1,2, Kyu-Ho Song¹, Chi-Hyeon Yoo^1,2, Dong-Cheol Woo², and Bo-Young Choe¹

¹Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, ²Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of

Nicotine effects the activation of nicotinic acetylcholine receptors (nAChRs) in multiple areas of the brain. Varenicline is a partial agonist acting at the α4β2 nAChRs. The purpose of the study is to compare the in vivo effects of nicotine and varenicline that contribute to the reward system. The results show the tendency of increased Glu level in nicotine group. Moreover, GSH and NAA levels tended to decrease in the nicotine group. It satisfies that high resolution and short TE component adequately spilt the overlapped metabolite spectra and quantify the cerebral neurochemicals. We found that varenicline effectively inhibits the reward cycle.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.