Abstract #3988

Choline metabolism is reprogrammed differently in mutant IDH1 cells

Pavithra Viswanath¹, Jose Izquierdo-Garcia¹, Larry Cai¹, Joanna Phillips², Russell Pieper², and Sabrina M Ronen¹

¹Radiology, University of California San Francisco, San Francisco, CA, United States, ²Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Abnormal choline metabolism with increased levels of phosphocholine (PC) driven by overexpression of choline kinase α is considered a hallmark of cancer. For the first time, we show that glioma cells with the IDH1 mutation reprogram choline metabolism differently. Using ¹³C-MRS to quantify [1,2-¹³C]-choline flux to PC in IDH1 mutant cells from two genetically engineered glioma models, we show that reduced PC synthesis is characteristic of mutant IDH1 cells. Furthermore, reduced PC synthesis is driven by down-regulated choline kinase α expression. Our study points to unusual reprogramming of choline metabolism in IDH1 mutant glioma cells, pointing to novel therapeutic opportunities.

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