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Abstract #3990

In vivo metabolite quantification using ERETIC with corrections for changes in the RF transmission and recepetion field

Niklaus Zoelch1, Andreas Hock1,2, and Anke Henning1,3

1Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 2Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

With ERETIC (Electric Reference To access In vivo Concentrations) metabolite signals measured in vivo are referenced to a signal measured in a phantom while directly correcting for differences in the coli loading conditions between the in vivo and in vitro measurement. This is beneficial compared to using an internal reference because no assumption about the concentration or the relaxation rate of the internal reference is need. However in contrast to the signal of an internal reference the ERETIC signal contains no information about B1 during transmission or reception and changes in B1 between the in vivo and in vitro measurement or at different positions are misinterpreted as metabolite concentration changes. The aim of this work was to tackle this problem by incorporating reception sensitivity corrections into the ERETIC method and by using a volume based power optimization to avoid differences during transmission. As a result, the obtained metabolite concentrations agree well with the values obtained with internal water referencing in healthy volunteers.

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