Abstract #3998

Simultaneous MEGA-PRESS editing of valine and lactate

Thomas Lange¹, Cheng-Wen Ko², Shang-Yueh Tsai³, Martin Buechert⁴, and Ping-Hong Lai⁵

¹Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ²Dept. of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, ³Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan, ⁴Magnetic Resonance Development and Application Center, University Medical Center Freiburg, Freiburg, Germany, ⁵Dept. of Radiology, Veterans General Hospital Kaohsiung, Kaohsiung, Taiwan

The MEGA-PRESS sequence allows difference editing of J-coupled metabolites on the basis of their specific coupling behavior. In this work, we demonstrate MEGA-PRESS editing of valine and lactate from a large background of lipid signal. Exploiting the very similar J-coupling constants of valine and lactate, it is demonstrated that both metabolites can be edited simultaneously with an echo time of 142 ms, allowing an editing efficiency of 100% with negligible lipid co-editing. Simultaneous valine/lactate editing is validated in vitro and successfully demonstrated in one brain abscess patient. The method may prove clinically useful for distinguishing brain abscesses from brain tumors.

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