Meeting Banner
Abstract #3998

Simultaneous MEGA-PRESS editing of valine and lactate

Thomas Lange1, Cheng-Wen Ko2, Shang-Yueh Tsai3, Martin Buechert4, and Ping-Hong Lai5

1Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 2Dept. of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, 3Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan, 4Magnetic Resonance Development and Application Center, University Medical Center Freiburg, Freiburg, Germany, 5Dept. of Radiology, Veterans General Hospital Kaohsiung, Kaohsiung, Taiwan

The MEGA-PRESS sequence allows difference editing of J-coupled metabolites on the basis of their specific coupling behavior. In this work, we demonstrate MEGA-PRESS editing of valine and lactate from a large background of lipid signal. Exploiting the very similar J-coupling constants of valine and lactate, it is demonstrated that both metabolites can be edited simultaneously with an echo time of 142 ms, allowing an editing efficiency of 100% with negligible lipid co-editing. Simultaneous valine/lactate editing is validated in vitro and successfully demonstrated in one brain abscess patient. The method may prove clinically useful for distinguishing brain abscesses from brain tumors.

This abstract and the presentation materials are available to members only; a login is required.

Join Here