Abstract #3997

Volumetric Navigated MEGA-SPECIAL for real-time zero- and first-order shim and motion corrected GABA MRS

Muhammad Gulamabbas Saleh¹, Jamie Near², A Alhamud¹, Lindie du Plessis¹, André J.W. van der Kouwe³, and Ernesta M Meintjes¹

¹Human Biology, MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, South Africa, ²Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

During macromolecule (MM) suppressed GABA MRS acquisition, subject motion may cause the spectra to be acquired at an incorrect region of interest and with suboptimal shim. Furthermore, effective MM-suppression requires the editing pulses to be applied consistently at 1.7 ppm, necessitating real-time frequency updates, which can be exacerbated in the presence of motion. We demonstrate that a pair of 3D EPI volumetric navigators acquired once per TR is able to perform accurate motion and magnetic field inhomogeneity correction in real time during MM-suppressed MEGA-SPECIAL GABA MRS.

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