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Abstract #3996

J-Difference Editing of 2-Hydroxyglutarate

Kimberly L Chan1,2,3, Richard AE Edden2,3, and Peter B Barker2,3

1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

2-hydroxyglutarate (2HG) is formed in some brain tumors due to a mutation of isocitrate dehydrogenase (IDH), and is becoming an important biomarker for tumor classification. Various approaches have been proposed for the in vivo measurement of 2HG using MR spectroscopy, including spectral-editing using the MEGA-PRESS technique. This abstract investigates 2HG editing at 3T using density-matrix simulations and phantom experiments. It is demonstrated that MEGA-PRESS detection of 2HG is best performed at an echo time of 100 ms, applying editing pulses to the 1.9 ppm spins and detecting the 4.0 ppm signal, and employing high-bandwidth refocusing pulses.

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