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Abstract #3995

Dual J-difference editing of glutathione and lactate at 3T

Kimberly L Chan1,2,3, Karim Snoussi2,3, Richard AE Edden2,3, and Peter B Barker2,3

1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Glutathione (GSH), a redox metabolite, and lactate, a product of anaerobic energy metabolism, can both be detected in the human brain using J-difference editing. Editing each will usually co-edit the other to some degree, as the GSH editing target spin is at 4.56 ppm and the lactate spin is at 4.1 ppm. In this abstract, we investigate optimal simultaneous detection of both metabolites, using a combination of simulations, and phantom and in vivo experiments. We demonstrate a new acquisition protocol applying 10 ms editing pulses at 4.35 ppm, which successfully edits both GSH and lactate signals with near maximal efficiency.

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