Abstract #3994

Macromolecule Suppressed GABA Editing using MEGA-SPECIAL Sequence with Spectral-spatial RF Pulse

Meng Gu¹, Adam Kerr², Ralph Hurd³, and Daniel Spielman¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Electrical Engineering, Stanford University, Stanford, CA, United States, ³GE Healthcare, Menlo Park, CA, United States

MEGA PRESS has been used to edit the GABA resonance at 3ppm. Due to the wide transition bandwidth of the editing pulse, macromolecule resonances are coedited. To suppress macromolecule signals, a symmetric suppression method has been proposed resulting in reduced GABA signal. We present a new editing method by incorporating spatial and spectral selectivity into the SPECIAL refocusing RF pulses to achieve both GABA editing and macromolecule suppression. Phantom studies showed higher edited GABA signal compared with MEGA PRESS and 90% macromolecule suppression. In-vivo studies demonstrated significantly higher edited GABA signal compared with MEGA PRESS.

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