Macromolecule Suppressed GABA Editing using MEGA-SPECIAL Sequence with Spectral-spatial RF Pulse
Meng Gu1, Adam Kerr2, Ralph Hurd3, and Daniel Spielman1
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States, 3GE Healthcare, Menlo Park, CA, United States
MEGA PRESS has been used to edit the GABA resonance
at 3ppm. Due to the wide transition bandwidth of the editing pulse,
macromolecule resonances are coedited. To suppress macromolecule signals, a
symmetric suppression method has been proposed resulting in reduced GABA
signal. We present a new editing method by incorporating spatial and spectral
selectivity into the SPECIAL refocusing RF pulses to achieve both GABA editing
and macromolecule suppression. Phantom studies showed higher edited GABA signal
compared with MEGA PRESS and 90% macromolecule suppression. In-vivo studies
demonstrated significantly higher edited GABA signal compared with MEGA PRESS.
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