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Abstract #4000

Quantitative Imaging of ATP Production Rates and their Functional Changes in Healthy Human Brain

Xiao-Hong Zhu1, Byeong-Yeul Lee1, and Wei Chen1

1CMRR, Radiology Department, University of Minnesota, Minneapolis, MN, United States

We established a practical protocol for quantitatively imaging the cerebral metabolic rates of ATP production via ATPase and creatine kinase (CK) reactions in human brain at 7T using three dimensional (3D) chemical shift imaging (CSI) and in vivo 31P MR spectroscopy (MRS) in combine with magnetization transfer (MT) approach. Subsequently, we applied this 3D 31P-MT imaging protocol to quantify the regional phosphorous metabolites concentrations, ATPase and CK reaction rate constants and fluxes and the intracellular pH in human brain at rest and during visual stimulation. The results of this study provide the values of key parameters relevant to ATP metabolism in absolute scale, which allow quantitative evaluation of regional cerebral energetics in resting human brain and its functional changes.

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