Abstract #4001

CSF fraction calculation for single voxel spectroscopy: comparison of water signal T2 biexponential fitting and image segmentation in a pediatric population

Frances C Robertson¹, Martha J Holmes¹, Francesca Little², Mark F Cotton³, Els Dobbels³, Andre JW van der Kouwe^4,5, Barbara Laughton³, and Ernesta M Meintjes¹

¹Department of Human Biology, University of Cape Town, Cape Town, South Africa, ²Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa, ³Department of Paediatrics & Child Health, Stellenbosch University, Stellenbosch, South Africa, ⁴A.A. Martinos Centre for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States

For partial volume correction in ¹H-MRS the voxel fraction of brain matter (BM) and cerebral spinal fluid (CSF) can be calculated via biexponential fitting of T2 relaxation of the unsuppressed water signal or via segmentation of a high-resolution structural image. We compared voxel CSF percentages obtained using these two methods and investigated whether discrepancies could be explained by head movement between voxel positioning and MRS acquisition. Subjects with large differences in CSF% between methods tended to show greater displacement than those with no difference between methods. Inconsistencies may be due to segmentation inaccuracy in particular regions or subject motion.

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