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Abstract #4001

CSF fraction calculation for single voxel spectroscopy: comparison of water signal T2 biexponential fitting and image segmentation in a pediatric population

Frances C Robertson1, Martha J Holmes1, Francesca Little2, Mark F Cotton3, Els Dobbels3, Andre JW van der Kouwe4,5, Barbara Laughton3, and Ernesta M Meintjes1

1Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa, 3Department of Paediatrics & Child Health, Stellenbosch University, Stellenbosch, South Africa, 4A.A. Martinos Centre for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States

For partial volume correction in 1H-MRS the voxel fraction of brain matter (BM) and cerebral spinal fluid (CSF) can be calculated via biexponential fitting of T2 relaxation of the unsuppressed water signal or via segmentation of a high-resolution structural image. We compared voxel CSF percentages obtained using these two methods and investigated whether discrepancies could be explained by head movement between voxel positioning and MRS acquisition. Subjects with large differences in CSF% between methods tended to show greater displacement than those with no difference between methods. Inconsistencies may be due to segmentation inaccuracy in particular regions or subject motion.

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