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Abstract #4010

Downfield spectra of human brain obtained with and without water suppression at 9.4T

Nicole D Fichtner1,2, Ioannis Giapitzakis3, Nikolai Avdievich3, Anke Henning2,3, and Roland Kreis1

1Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland, 2Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

Ultra high field strengths offer the benefit of higher signal to noise ratio as well as improved separation of metabolites in spectroscopy, which is beneficial for evaluating downfield peaks. In the current work, the metabolite cycling technique is implemented at 9.4T in order to evaluate the downfield part of the human brain spectrum. The 9.4T spectra confirm the 3T findings on exchanging peaks, and indicate that the higher field strength improves metabolite separation, allowing for better quantification of exchanging peaks, which is also of great interest for chemical exchange dependent saturation transfer experiments.

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