Abstract #4011

1H MRS of gray and white matter in the human brain using B0 Adjusted Sensitivity Encoded Spectral Localization by Imaging (BASE-SLIM)

Peter Adany¹, Phil Lee^1,2, and In-Young Choi^1,2,3

¹Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, ²Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, ³Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States

Reliable localization of ¹H MRS in gray and white matter of the human brain was achieved using the BASE-SLIM technique. Distinctive spectral patterns of gray and white matter were measured from all subjects using BASE-SLIM, which were consistent with those measured in both tissue types using single-voxel ¹H MRS. BASE-SLIM spectroscopy promises 1) accurate and robust acquisition of MR spectra from gray and white matter with minimum cross contamination from other compartments, 2) shorter scan time and 3) flexibility in compartmental shapes that match anatomical structures.

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