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Abstract #4012

Parameter optimization for reproducible cardiac 1H-MR Spectroscopy at 3 T

Paul de Heer1, Maurice B Bizino2, Hildo J Lamb2, and Andrew G Webb1

1CJ Gorter Center, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

Cardiac proton MR spectroscopy is a challenging technique to perform in a reliable manner. In this study data acquisition parameters are optimized in terms of signal-to-noise and reproducibility. The optimal protocol was determined to be a PRESS localized scan, local power optimization, pencil beam B0 shimming, a cardiac trigger delay of 200 ms, MOIST water suppression and pencil beam navigator-based respiratory compensation. With these parameters high intra- (r=1.000, p<0.0001) and inter- (r=1.000, p=0.0004) session reproducibilities were achieved. Bland-Altman analysis showed limits of agreement from -0.11 to 0.04 (intra) and -0.15 to 0.9.

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