Abstract #4014

1H-MRS ultra-long echo time PRESS detects omega-3 fatty acids in vivo at 7T

Martin Gajdošík^1,2, Lukas Hingerl¹, Petr Šedivý³, Miloslav Drobný³, Monika Dezortová³, Michael Krebs⁴, Siegfried Trattnig^1,2, Wolfgang Bogner¹, and Martin Krššák^1,2,4

¹High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³MR Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

Omega-3 (n-3) fatty acids are essential to human health. However, the knowledge about their tissue concentrations is not well established. The spectral dispersion at 7T yields a sufficient spectral separation of n-3 (n-3 CH₃) and non n-3 methyl (CH₃) groups. Large differences in the T₂ relaxation and J-modulation of outer triplet lines allowed for excellent separation of the n-3 CH₃ signal and for estimation of its relative concentration in adipose tissue for the detection by ¹H MR PRESS with TE of 1000ms.

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