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Abstract #4014

1H-MRS ultra-long echo time PRESS detects omega-3 fatty acids in vivo at 7T

Martin Gajdošík1,2, Lukas Hingerl1, Petr Šedivý3, Miloslav Drobný3, Monika Dezortová3, Michael Krebs4, Siegfried Trattnig1,2, Wolfgang Bogner1, and Martin Krššák1,2,4

1High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3MR Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 4Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

Omega-3 (n-3) fatty acids are essential to human health. However, the knowledge about their tissue concentrations is not well established. The spectral dispersion at 7T yields a sufficient spectral separation of n-3 (n-3 CH3) and non n-3 methyl (CH3) groups. Large differences in the T2 relaxation and J-modulation of outer triplet lines allowed for excellent separation of the n-3 CH3 signal and for estimation of its relative concentration in adipose tissue for the detection by 1H MR PRESS with TE of 1000ms.

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