Abstract #4017

Investigating the effects of decoupling on in vivo 13C MRS to optimize acquisition in glycogen studies

Stephen Bawden^1,2, Paul Glover¹, Peter Morris¹, Guruprasad Aithal², and Penny Gowland¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Digestive Diseases Research Unit, University of Nottingham, Nottingham, United Kingdom

In this study the decoupling efficiency of in vivo 13C MRS measurements of glycogen levels was assessed. Due to SAR restrictions and surface coil decoupling field inhomogeneity, this study showed that short TR coupled spectroscopy provides improved SNR and better defined spectral parameters for fitting, whereas decoupled spectra reduces the number of averages in the same timeframe and runs the risk of varying residual coupling constants across a large field of view with inhomogeneous B₂

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