Abstract #4018

Longitudinal relaxation time editing for acetylcarnitine detection with 1H-MRS

Lucas Lindeboom^1,2, Yvonne M.H. Bruls^1,2, Petronella A. van Ewijk¹, Matthijs K.C. Hesselink², Joachim E. Wildberger¹, Patrick Schrauwen², and Vera B. Schrauwen-Hinderling^1,2

¹Radiology, Maastricht University Medical Center, Maastricht, Netherlands, ²Human Biology and Human Movement Sciences, Maastricht University Medical Center, Maastricht, Netherlands

The use of a long TE enables detection of acetylcarnitine with ¹H-MRS. However, in (very) obese subjects, suppression of overlapping lipid resonances becomes problematic, even with long TE. We here show short T₁ metabolites, such as lipids, can additionally be suppressed with a new T₁editing approach.

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