Abstract #4019

Kinetic modelling of hyperpolarized13C-pyruvate metabolism in Canines using a model-based input function

Nikolaos Dikaios¹, Shonit Punwani¹, Henrik Gutte², Majbrit ME Larsen³, Annemarie T Kristensen³, Andreas Kjær², David Atkinson⁴, and Adam E Hansen²

¹Centre of Medical Imaging, UCL, London, United Kingdom, ²Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ³Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Centre for Medical Imaging, UCL, London, United Kingdom

Mathematical models based on kinetic parameters allow us to investigate ¹³C-pyruvate metabolism. Metabolic exchanges between pyruvate and its metabolites can differentiate benign from malignant tissue but their quantification is limited by the estimation of the arterial input function (AIF). This work suggests to model the AIF using a Gaussian pdf to account for the time pyruvate needs to travel and dispersion effects. The proposed AIF fits the measured data better than the commonly used box-car AIF, and is in agreement with the model-free formalism which approximates the kinetics using the ratios of AUC of the injected and product metabolites.

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