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Abstract #4019

Kinetic modelling of hyperpolarized13C-pyruvate metabolism in Canines using a model-based input function

Nikolaos Dikaios1, Shonit Punwani1, Henrik Gutte2, Majbrit ME Larsen3, Annemarie T Kristensen3, Andreas Kjær2, David Atkinson4, and Adam E Hansen2

1Centre of Medical Imaging, UCL, London, United Kingdom, 2Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 4Centre for Medical Imaging, UCL, London, United Kingdom

Mathematical models based on kinetic parameters allow us to investigate 13C-pyruvate metabolism. Metabolic exchanges between pyruvate and its metabolites can differentiate benign from malignant tissue but their quantification is limited by the estimation of the arterial input function (AIF). This work suggests to model the AIF using a Gaussian pdf to account for the time pyruvate needs to travel and dispersion effects. The proposed AIF fits the measured data better than the commonly used box-car AIF, and is in agreement with the model-free formalism which approximates the kinetics using the ratios of AUC of the injected and product metabolites.

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