quantitation framework on highly resolved 2D CT-PRESS spectra with 1H
decoupling was proposed for measurement of concentration of glutamate and GABA.
Although peaks of these metabolites are clearly resolved on the spectra, long
constant time delay (Tct) requires T2 correction. To overcome
this, we proposed a fast T2 correction method using 2D FT with shared
time domain data. After curve fitting of series of spectra with varied Tct's,
we obtained series of peak volumes that can be expressed as an exponential
decay of T2. In phantom experiments, we could measure the
concentrations of glutamate and GABA by our method.