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Abstract #4023

Simultaneous absolute quantitation of glutamate and GABA on highly resolved 2D constant time PRESS spectra using 2D FT with shared time domain data

Hidehiro Watanabe1 and Nobuhiro Takaya1

1Center for Environmental Measurement and Analysis, National Institute for Environmental Studies, Ibaraki, Japan

Absolute quantitation framework on highly resolved 2D CT-PRESS spectra with 1H decoupling was proposed for measurement of concentration of glutamate and GABA. Although peaks of these metabolites are clearly resolved on the spectra, long constant time delay (Tct) requires T2 correction. To overcome this, we proposed a fast T2 correction method using 2D FT with shared time domain data. After curve fitting of series of spectra with varied Tct's, we obtained series of peak volumes that can be expressed as an exponential decay of T2. In phantom experiments, we could measure the concentrations of glutamate and GABA by our method.

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