Abstract #4023

Simultaneous absolute quantitation of glutamate and GABA on highly resolved 2D constant time PRESS spectra using 2D FT with shared time domain data

Hidehiro Watanabe¹ and Nobuhiro Takaya¹

¹Center for Environmental Measurement and Analysis, National Institute for Environmental Studies, Ibaraki, Japan

Absolute quantitation framework on highly resolved 2D CT-PRESS spectra with ¹H decoupling was proposed for measurement of concentration of glutamate and GABA. Although peaks of these metabolites are clearly resolved on the spectra, long constant time delay (T_ct) requires T₂ correction. To overcome this, we proposed a fast T₂ correction method using 2D FT with shared time domain data. After curve fitting of series of spectra with varied T_ct's, we obtained series of peak volumes that can be expressed as an exponential decay of T₂. In phantom experiments, we could measure the concentrations of glutamate and GABA by our method.

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