Abstract #4022

Metabolic profiling of normal hepatocyte and hepatocarcinoma cell lines related to metastasis potentials by 1H NMR spectroscopy and chemometrics

Yang Chen¹, Jianghua Feng¹, Naishun Liao², Ying Su³, Changyan Zou³, and Zhong Chen¹

¹Department of Electronic Science, Xiamen University, Xiamen, China, People's Republic of, ²The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, MengChao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China, People's Republic of, ³Laboratory of Radiobiology, Fujian Provincial Tumor Hospital, Fuzhou, China, People's Republic of

To explore metabolic characteristics of hepatocarcinoma cell lines associated with different metastasis potentials, ¹H NMR-based metabolomics conjugated with multivariate statistical analysis were performed to determine the molecular mechanisms of metastasis. Characteristic metabolites from both cell extracts and cultured medium were identified. Our results provide evidences that cells with different metastasis potentials exhibit different levels of glucose consumption, as well as the products of some intermediates of glycolysis.

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