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Abstract #4022

Metabolic profiling of normal hepatocyte and hepatocarcinoma cell lines related to metastasis potentials by 1H NMR spectroscopy and chemometrics

Yang Chen1, Jianghua Feng1, Naishun Liao2, Ying Su3, Changyan Zou3, and Zhong Chen1

1Department of Electronic Science, Xiamen University, Xiamen, China, People's Republic of, 2The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, MengChao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China, People's Republic of, 3Laboratory of Radiobiology, Fujian Provincial Tumor Hospital, Fuzhou, China, People's Republic of

To explore metabolic characteristics of hepatocarcinoma cell lines associated with different metastasis potentials, 1H NMR-based metabolomics conjugated with multivariate statistical analysis were performed to determine the molecular mechanisms of metastasis. Characteristic metabolites from both cell extracts and cultured medium were identified. Our results provide evidences that cells with different metastasis potentials exhibit different levels of glucose consumption, as well as the products of some intermediates of glycolysis.

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