Abstract #4021

Study of MS Tissue Injury and Repair with In Vivo MR Spectroscopy of Lipids and Proteins - First Results

Christoph Juchem¹, Hetty Prinsen¹, Kevin L Behar¹, Robert K Fulbright¹, and Douglas L Rothman¹

¹Yale University, New Haven, CT, United States

Altered lipid and protein contents have been detected with MR spectroscopy in acute multiple sclerosis lesions and speculated to reflect de- and remyelination processes. To date, however, neither the metabolites involved nor their pathological relevance have been satisfactorily described. Hofmann et al. introduced an elegant concept for the separation of biochemicals of varying metabolic weight based on differences in T1 relaxation behavior (MRM 46, 2001). Here, we describe T1-encoded MR spectroscopy at 7 Tesla, the extraction of individual, spectroscopically overlapping lipid/protein signals by two-dimensional processing and initial applications to the study of the pathological processes associated to multiple sclerosis tissue injury and repair.

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