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Abstract #4025

Grey and white matter signal separation in the single voxel NMR spectroscopy at 7T

Donghyun Hong1, Jack JA van Asten2, Seyedmorteza Rohani Rankouhi1, Jan-Willem Thielen1, and David G. Norris1,3

1Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, 2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 3Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

GABA spectroscopy has two potential confounds widely ignored by the spectroscopic community: 1) a potential 5-10Hz frequency shift between grey and white matter shown in imaging experiment and 2) the fact that the GABA is circa 9 times more concentrated in grey matter. To investigate whether these confounds could affect GABA spectroscopy at 7T, we compute grey and white matter lineshapes by frequency mapping. We found a slight frequency shift and lineshape which can be ignored. Hence, we conclude that we can probably safely use a single lineshape for fitting using LCModel.

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