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Abstract #4026

Potential of 3T fMRS to detect dynamic changes of glutamate related to activation in visual cortex

Miguel Martínez-Maestro1, Christian Labadie2, Karsten Mueller1, and Harald E. Möller1

1NMR Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Charité - Berlin Center for Advanced Neuroimaging (BCAN), Berlin, Germany

Dynamic changes of metabolite concentrations in the human brain have been successfully detected in response to stimulus at 7T. The present study focus on characterize the detection limits at 3T. 20min fMRS paradigm alternated 5min intervals with stimulus OFF/ON/OFF/ON. A significant intra-individual increase in glutamate+glutamine (Glx) was found in the group analysis (1.83%, p = 0.017). The cross-subjects averaged time course also indicated 1.98% concentration increase during the ON periods. A direct correlation between subtle changes of Glx concentrations and the application of a visual stimulus could be shown consistent with reports from ultra-high field studies.

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