Abstract #4027

GABA+ levels in postmenopausal women with mild-to-moderate depression: A Preliminary Study

Zhensong Wang^1,2, Aiying Zhang³, Jie Gan², Guangbin Wang¹, Bin Zhao¹, Huifang Qu⁴, Weibo Chen⁵, Bo Liu⁶, Fei Gao¹, Tao Gong⁷, and Richard A.E. Edden^8,9

¹Shandong Medical Imaging Research Institute, Jinan, China, People's Republic of, ²Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China, People's Republic of, ³Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China, People's Republic of, ⁴Shandong Chest Hospital, Jinan, China, People's Republic of, ⁵Philips Healthcare, Shanghai, China, People's Republic of, ⁶QiLu Hospital of Shandong University, Jina, China, People's Republic of, ⁷Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, People's Republic of, ⁸Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA, Baltimore, MD, United States, ⁹FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA, Baltimore, MD, United States

The present study hypothesized that the GABA levels would be lower in postmenopausal women with mild-to-moderate depression. We investigate the cerebral GABA levels in postmenopausal women using the edited MRS technique MEGA-PRESS. 18 postmenopausal women with mild-to-moderate depression and 11 healthy controls with the age- and body index-, educationally matched were enrolled. GABA+ levels were quantified in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and the posterior cingulated cortex (PCC). Water-scaled GABA+ levels were significantly lower in the ACC/mPFC regions of patients group than in healthy controls, which suggesting that dysfunctional GABAergic system may be involved in depression in postmenopausal women.

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