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Abstract #4028

Simultaneous assessment of cerebral iron load, as estimated by Quantitative Susceptibility Mapping, and Amyloid-β plaque density, as measured by 18F-Flutametamol, in Super-agers

Jiri M.G. van Bergen1, Xu Li2, Frances C. Quevenco1, Anton F. Gietl1, Valerie Treyer1,3, Rafael Meyer1, Sandra E. Leh1, Alfred Buck3, Roger Nitsch1, Peter C.M. van Zijl2, Christoph Hock1, and Paul G. Unschuld1

1Psychiatry Research and Psychogeriatric Medicine, University of Zurich, Zurich, Switzerland, 2F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, Baltimore, MD, United States, 3Division of Nuclear Medicine, University of Zurich, Zurich, Switzerland

We investigated “super-agers” (a minority of elderly subjects that display significantly higher cognitive performance levels) for the interaction of Aβ-plaque burden and iron load, using Quantitative Susceptibility Mapping and simultaneous 18F-Flutametamol measures in the PET-MR. We found significant increased iron load in the putamen and caudate nucleus of subjects with a high Aβ-plaque burden, but no regional correlations between the two markers in gray matter. This suggests that while super-agers are affected by common age-related brain pathologies, such as cortical Aβ-plaque burden and increased striatal iron load, these might exert less neurotoxic damage.

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