Abstract #4029

The glutamine and glutamate complex measured by functional MRS alters during a face-name association task in patients with MCI and AD

Geon-Ho Jahng¹, Janghoon Oh¹, Hyug-Gi Kim¹, Do-Wan Lee², Chanhee Lee¹, Hak Young Rhee³, Chang-Woo Ryu¹, Wonchul Shin³, Jong-Woo Paik⁴, Kyung Mi Lee⁵, Soonchan Park¹, Bo-Young Choe², and Dal-Mo Yang¹

¹Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of, ²Department of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of, ⁴Department of Mental Health, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea, Republic of, ⁵Department of Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea, Republic of

To investigate the metabolite changes in subjects with AD, MCI, and cognitively normal (CN) elderly during a memory task using dynamic MRS at a 3T MRI system, we included 95 subjects who included: 23 young normal control (YC), 24 cognitively normal (CN) elderly, 24 aMCI, and 24 mild and probable AD. The functional MRS data were measured during the face-name association task with the stimulation paradigm of fixation, novel, and repeat conditions. The fMRS data were analyzed using the LCModel software. Glx was altered during the stimulation conditions, which can be used in neuronal dysfunction for a patient with dementia.

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