Abstract #4037

White matter lesion volume does not affect the relationship between CSF Aβ42 and cerebral amyloid deposition assessed with PET

Danielle van Westen¹, Sebastian Palmqvist², Henrik Zetterberg³, Niklas Mattsson², Lennart Minthon², Katarina Nägga², Erik Stomrud², The Swedish BioFINDER study², Kaj Blennow³, and Oskar Hansson²

¹Diagnostic Radiology, Lund University, Lund, Sweden, ²Memory Clinic, Lund University, Lund, Sweden, ³The Sahlgrenska Academy at University of Gothenburg, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Gothenburg, Sweden

White matter lesions (WML) are abundant in the elderly and even more so in Alzheimer’s disease (AD). Previous studies indicate that WML affect the level of cerebrospinal fluid (CSF) Aβ42 and this in turn might affect the validity of CSF Aβ42 as biomarker of the pathological hallmark of AD, namely cerebral amyloid deposition. Therefore, we studied the influence of WML on the association between CSF Aβ42 and amyloid deposition measured with [18F]-flutemetamol positron emission tomography (PET).

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