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Abstract #4037

White matter lesion volume does not affect the relationship between CSF Aβ42 and cerebral amyloid deposition assessed with PET

Danielle van Westen1, Sebastian Palmqvist2, Henrik Zetterberg3, Niklas Mattsson2, Lennart Minthon2, Katarina Nägga2, Erik Stomrud2, The Swedish BioFINDER study2, Kaj Blennow3, and Oskar Hansson2

1Diagnostic Radiology, Lund University, Lund, Sweden, 2Memory Clinic, Lund University, Lund, Sweden, 3The Sahlgrenska Academy at University of Gothenburg, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Gothenburg, Sweden

White matter lesions (WML) are abundant in the elderly and even more so in Alzheimer’s disease (AD). Previous studies indicate that WML affect the level of cerebrospinal fluid (CSF) Aβ42 and this in turn might affect the validity of CSF Aβ42 as biomarker of the pathological hallmark of AD, namely cerebral amyloid deposition. Therefore, we studied the influence of WML on the association between CSF Aβ42 and amyloid deposition measured with [18F]-flutemetamol positron emission tomography (PET).

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