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Abstract #4038

Voxel-Based Analysis of Cerebral Perfusion in Subcortical Ischemic Vascular Dementia and Alzheimer’s Disease Dementia: a Multi-Parametric Multi-TI Arterial-Spin-Labeling Study

Shuang Yang1, Tianyi Qian2, Yao Meng3, Fei Gao1, Josef Pfeuffer4, Guangbin Wang1, and Bin Zhao1

1Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, People's Republic of, 2Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of, 3Shandong provincial Hospital, Shandong University, Jinan, China, People's Republic of, 4Siemens Healthcare, Application Development, Erlangen, Germany

This study aims to present the feasibility of multi-TI (mTI)-ASL in distinguishing between AD and SIVD patients in cerebral perfusion. Nineteen SIVD subjects, twelve AD subjects, and ten controls were included in the study. There was no significant difference in CBF between SIVD and HCs, and between SIVD and AD patients. However, significant differences of BAT were detected among all three groups. The mTI-ASL could evaluate the cerebral perfusion of AD and SIVD patients. Compared with CBF, the BAT could better detect perfusion differences and demonstrated better efficiency.

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