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Abstract #4040

Temperature effects in post mortem structural MRI of human brain in situ

Gunther Helms1,2, Arne Wrede3, Peter Dechent2, and Walter Schulz-Schaeffer3

1Medical Radiation Physics, Lund University, Lund, Sweden, 2Cognitive Neurology, Göttingen University Medical Center, Göttingen, Germany, 3Neuropathology, Göttingen University Medical Center, Göttingen, Germany

Structural 3D MRI and FLASH-based mapping of T1 and magnetization transfer (MT) at 3T was performed in situ on 11 subjects with probable Creutzfeldt-Jacob disease prior to autopsy. The mean diffusivity in ventricles yielded temperatures between 6°C and 29°C. T1 contrast in the deep brain decreased with temperature and vanished under refrigerated conditions. T1 of gray matter lowered towards the normal white matter’s T1 which did not change. The MT saturation was generally independent of temperature, except in normal WM below 13°C. Above 13°C, MT maps yield a high contrast and can be used for quantitative assessment of structural changes.

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