Temperature effects in post mortem structural MRI of human brain in situ
Gunther Helms1,2, Arne Wrede3, Peter Dechent2, and Walter Schulz-Schaeffer3
1Medical Radiation Physics, Lund University, Lund, Sweden, 2Cognitive Neurology, Göttingen University Medical Center, Göttingen, Germany, 3Neuropathology, Göttingen University Medical Center, Göttingen, Germany
Structural 3D MRI and FLASH-based mapping of T1 and magnetization
transfer (MT) at 3T was performed in situ on 11 subjects with probable Creutzfeldt-Jacob
disease prior to autopsy. The mean diffusivity in ventricles
yielded temperatures between 6°C and 29°C. T1 contrast in the deep brain decreased with
temperature and vanished under refrigerated conditions. T1 of gray matter
lowered towards the normal white matter’s T1 which did not change. The MT
saturation was generally independent of temperature, except in normal WM below 13°C. Above
13°C, MT maps yield a high contrast and can be used for quantitative assessment
of structural changes.
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