Abstract #4040

Temperature effects in post mortem structural MRI of human brain in situ

Gunther Helms^1,2, Arne Wrede³, Peter Dechent², and Walter Schulz-Schaeffer³

¹Medical Radiation Physics, Lund University, Lund, Sweden, ²Cognitive Neurology, Göttingen University Medical Center, Göttingen, Germany, ³Neuropathology, Göttingen University Medical Center, Göttingen, Germany

Structural 3D MRI and FLASH-based mapping of T₁ and magnetization transfer (MT) at 3T was performed in situ on 11 subjects with probable Creutzfeldt-Jacob disease prior to autopsy. The mean diffusivity in ventricles yielded temperatures between 6°C and 29°C. T₁ contrast in the deep brain decreased with temperature and vanished under refrigerated conditions. T₁ of gray matter lowered towards the normal white matter’s T₁ which did not change. The MT saturation was generally independent of temperature, except in normal WM below 13°C. Above 13°C, MT maps yield a high contrast and can be used for quantitative assessment of structural changes.

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