Meeting Banner
Abstract #4041

Histological correlates of MRI contrast in patients with Alzheimer’s Disease

Marjolein Bulk1, Walid M. Abdelmoula1, Linda M. van der Graaf1, Mark A. van Buchem1, Pieter Voorn2, Jouke Dijkstra1, and Louise van der Weerd1,3

1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, Netherlands, 3Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Investigating the histological correlates of MRI contrasts in patients with Alzheimer’s disease (AD) will give more insight into the pathological correlates of T2* and SWI. Using 7T MRI and histology of post-mortem brain tissue we showed that the frontal cortex of AD patients has a different imaging phenotype compared to non-demented controls, which spatially correlates to changes in iron deposition and grey matter myelin organization Most importantly, within the AD group the early-onset AD patients are distinguishable on MRI from the late-onset AD patients, and these differences are mirrored in the underlying pathology of these AD subtypes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here