Abstract #4041

Histological correlates of MRI contrast in patients with Alzheimer’s Disease

Marjolein Bulk¹, Walid M. Abdelmoula¹, Linda M. van der Graaf¹, Mark A. van Buchem¹, Pieter Voorn², Jouke Dijkstra¹, and Louise van der Weerd^1,3

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, Netherlands, ³Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Investigating the histological correlates of MRI contrasts in patients with Alzheimer’s disease (AD) will give more insight into the pathological correlates of T2* and SWI. Using 7T MRI and histology of post-mortem brain tissue we showed that the frontal cortex of AD patients has a different imaging phenotype compared to non-demented controls, which spatially correlates to changes in iron deposition and grey matter myelin organization Most importantly, within the AD group the early-onset AD patients are distinguishable on MRI from the late-onset AD patients, and these differences are mirrored in the underlying pathology of these AD subtypes.

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