Abstract #4042

Probing the effects of elevated glucose level on the integrity of white matter in Alzheimer’s disease using diffusion kurtosis imaging

Weiwei Wang¹, Jing Jing¹, Bing Wu², Ailian Liu¹, Qingwei Song¹, and Yanwei Miao¹

¹Radiology Department, the First Affiliated Hospital of Dalian Medical University, Dalian, China, People's Republic of, ²GE Healthcare MR Research China, BeiJing, China, People's Republic of

AD concomitant with hyperglycemia is commonly observed during clinical work, and it was known that AD and disorder of glucose metabolism are related.However, the factor of glucose level in AD patients have not yet been taken into consideration in the past studies, which might be of clinical significance in learning the AD progression. In this work, DKI is used to probe the likely effects of elevated glucose level in the white matter microstructure of AD patients.

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