Junxiao Yu1, Aikaterini Kotrotsou1, Arnold M. Evia1, Julie A. Schneider2, Sue E. Leurgans2, David A. Bennett2, and Konstantinos Arfanakis1
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States
Transactive response DNA-binding protein 43 (TDP43)
pathology was the primary protein abnormality in amyotrophic lateral
sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Recent
findings showed that TDP43 pathology is common in old age and
strongly associated with cognition, cognitive decline and increased
risk of dementia beyond the contributions of other age-related neuropathologies.
TDP43 pathology in aging is mainly found in the medial temporal lobes with the
being one of the first regions to be affected. The purpose of this project was
to study associations of TDP43 in aging with amygdalar volume for the first
time in a large community cohort.