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Abstract #4044

TDP43 correlates of amygdala volume in aging with ex-vivo MRI

Junxiao Yu1, Aikaterini Kotrotsou1, Arnold M. Evia1, Julie A. Schneider2, Sue E. Leurgans2, David A. Bennett2, and Konstantinos Arfanakis1

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Transactive response DNA-binding protein 43 (TDP43) pathology was the primary protein abnormality in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Recent findings showed that TDP43 pathology is common in old age and strongly associated with cognition, cognitive decline and increased risk of dementia beyond the contributions of other age-related neuropathologies. TDP43 pathology in aging is mainly found in the medial temporal lobes with the being one of the first regions to be affected. The purpose of this project was to study associations of TDP43 in aging with amygdalar volume for the first time in a large community cohort.

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