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Abstract #4045

Gender Based Analyses of Cortical Thickness and Structural Networks Connectivity in Parkinson’s Disease

Santosh Kumar Yadav1, Georgia Vasileiou2, Anup Singh3, Elias R Melhem4, Ena Wang1, Francesco M Marincola1, Arijitt Borthakur5, and Mohammad Haris1

1Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 2Department of Medical physics, University college of Landon, Landon, United Kingdom, 3Center for Biomedical Engineering, Indian institute of Technology, Delhi, India, 4Department of diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, 5Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

We evaluated the gender based differences in cortical thickness and structural brain network connectivity in PD patients. Significantly reduced cortical thicknesses and disrupted structural networks connectivity appeared in PD males compared to PD females suggestive of more brain tissue changes in PD males than PD females. These male-specific cortical thickness changes and disrupted structural networks connectivity may contribute to or derive from physiological and genetically differences between males and females and may have significant implications in diagnosing and treating PD among the gender.

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