Abstract #4046

Investigating pathology-related functional connectivity in cognitively normal super-agers

Frances-Catherine Quevenco¹, Jiri van Bergen¹, Xu Li², Anton F. Gietl¹, Valerie Treyer^1,3, Rafael Meyer¹, Sandra E. Leh¹, Alfred Buck³, Roger Nitsch¹, Peter C. M. van Zijl², Christoph Hock¹, and Paul G. Unschuld¹

¹Psychiatric Research, University of Zurich, Zurich, Switzerland, ²F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, Baltimore, MD, United States, ³Division of Nuclear Medicine, University of Zurich, Zurich, Switzerland

To investigate early stages of preclinical Alzheimer’s, this study investigates the functional connectivity of 25 cognitively healthy elderly participants (“super agers”) in relation to cortical iron (using QSM) and cortical amyloid-beta load (18F-Flutemetamol PET). Functional connectivity analysis with the posterior cingulate cortex (PCC) as a seed found significant regional and temporal overlaps in primary DMN regions for groups with high iron and high amyloid. Despite the network synchronicities, a contrast between high iron and high amyloid networks found significant FC differences between the PCC, precuneus, hippocampus and parahippocampus which are DMN connections known to be affected by Aß-burden.

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