Abstract #4048

A follow-up study of hippocampal subfield atrophy in mild cognitive impairment with automatic segment method

XIANGZHU ZENG¹, HUISHU YUAN¹, YING LIU¹, and ZHENG WANG¹

¹RADIOLOGY, PEKING UNIVERSITY THIRD HOSPITAL, BEIJING, China, People's Republic of

Mild cognitive impairment (MCI) is often considered as an intermediate stage between normal aging and dementia, as reflected by a higher rate of conversion to clinical Alzheimer’s disease (AD) than in the normal elderly population. The hippocampal formation is a complex brain region with a primary role in memory function and vulnerable to neurodegenerative diseases. The aim of this research is to investigate the atrophy feature of hippocampal subfield and follow up the changes of hippocampal subfield in about two years by using automatic segmentation tool in patients with MCI.Our results suggest that compared to ICV, hippocampal subfield could be a more sensitive to detect cerebral changes of MCI. CA1, CA3 and left entorhinal cortex may be main subfields involved during MCI stage. Volumes of hippocampal subfield decreased in MCI patients and were positive correlation with clinical scores. There were also decreases in volumes of hippocampal subfield in MCI patients with the progress of the disease.

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