4D Flow MRI for assessing cerebral venous flow, a potential surrogate marker for capillary pulsatility in Alzheimer’s disease
Leonardo A Rivera-Rivera1, Tilman Schubert2, Kevin M Johnson1, Sterling C Johnson3, Patrick Turski2, and Oliver Wieben1,2
1Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 2Radiology, University of Wisconsin Madison, Madison, WI, United States, 3Medicine, University of Wisconsin Madison, Madison, WI, United States
Cerebral arteries are
often morphologically altered and dysfunctional in Alzheimer’s disease. In this
study, 4D flow MRI was used to assess cerebral venous flow, particularly mean blood
flow and pulsatility index in patients with AD, and in healthy age matched controls.
We found a statistically significant increase in pulsatility index and decrease
in mean flow for the AD in most venous segments. With the large volume coverage
and high temporal and spatial resolution, 4D flow MRI can provide additional
biomarkers of vascular health that can contribute to the identifying patients
who could benefit from interventions to improve circulatory system functions.
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