Abstract #4049

4D Flow MRI for assessing cerebral venous flow, a potential surrogate marker for capillary pulsatility in Alzheimer’s disease

Leonardo A Rivera-Rivera¹, Tilman Schubert², Kevin M Johnson¹, Sterling C Johnson³, Patrick Turski², and Oliver Wieben^1,2

¹Medical Physics, University of Wisconsin Madison, Madison, WI, United States, ²Radiology, University of Wisconsin Madison, Madison, WI, United States, ³Medicine, University of Wisconsin Madison, Madison, WI, United States

Cerebral arteries are often morphologically altered and dysfunctional in Alzheimer’s disease. In this study, 4D flow MRI was used to assess cerebral venous flow, particularly mean blood flow and pulsatility index in patients with AD, and in healthy age matched controls. We found a statistically significant increase in pulsatility index and decrease in mean flow for the AD in most venous segments. With the large volume coverage and high temporal and spatial resolution, 4D flow MRI can provide additional biomarkers of vascular health that can contribute to the identifying patients who could benefit from interventions to improve circulatory system functions.

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