Abstract #4050

Evaluation of blood brain barrier permeability in Alzheimer’s disease with DCE-MRI

Rexford Newbould¹, Brandon Whitcher², Christopher Long³, Shaila Shabbir⁴, Paul Matthews⁵, Andrew Lockhart⁴, Craig Ritchie⁵, and Eugenii Ilan Rabiner¹

¹Imanova, London, United Kingdom, ²Klarismo, London, United Kingdom, ³MIT Sloan School of Management, Cambridge, MA, United States, ⁴GSK, Brentford, United Kingdom, ⁵Imperial College London, London, United Kingdom

DCE 3T MRI data acquired from 6 subjects with previous diagnoses of AD, 2 subjects with vascular dementia, and 7 healthy controls group-matched for age and gender. Radiofrequency transmit (B1) field corrected Gd concentration values were calculated via dual-temporal resolution dynamic T1 mapping during and over 45 minutes post rapid Gd infusion. The extended Tofts model was used to determine the volume and rate transfer constants of BBB permeability in 11 regions of interest. No differences were detected between groups, implying BBB leakage in AD is slower than detectable in this experiment, or that BBB permeability in AD is moderated by an active transport mechanism.

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