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Abstract #4050

Evaluation of blood brain barrier permeability in Alzheimer’s disease with DCE-MRI

Rexford Newbould1, Brandon Whitcher2, Christopher Long3, Shaila Shabbir4, Paul Matthews5, Andrew Lockhart4, Craig Ritchie5, and Eugenii Ilan Rabiner1

1Imanova, London, United Kingdom, 2Klarismo, London, United Kingdom, 3MIT Sloan School of Management, Cambridge, MA, United States, 4GSK, Brentford, United Kingdom, 5Imperial College London, London, United Kingdom

DCE 3T MRI data acquired from 6 subjects with previous diagnoses of AD, 2 subjects with vascular dementia, and 7 healthy controls group-matched for age and gender. Radiofrequency transmit (B1) field corrected Gd concentration values were calculated via dual-temporal resolution dynamic T1 mapping during and over 45 minutes post rapid Gd infusion. The extended Tofts model was used to determine the volume and rate transfer constants of BBB permeability in 11 regions of interest. No differences were detected between groups, implying BBB leakage in AD is slower than detectable in this experiment, or that BBB permeability in AD is moderated by an active transport mechanism.

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