Jakob Meineke1, Fabian Wenzel1, Iain D. Wilkinson2, and Ulrich Katscher1
Quantitative
Susceptibility Mapping (QSM) is used to study the deep gray-matter nuclei of
patients with Alzheimer’s Disease (AD) and healthy control subjects. QSM is
performed using “Joint background-field removal and segmentation-Enhanced
Dipole Inversion” (JEDI), which leverages the information from automated
model-based segmentation and allows the compact single-step formulation of the
ill-posed inversion problem of QSM. The tissue magnetic susceptibility shows a
trend for increase in the amygdala and the putamen of AD patients as compared
to healthy control subjects, in agreement with previous studies.
