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Abstract #4051

Quantitative Susceptibility Mapping in Alzheimer’s Disease using Joint background-field removal and segmentation-Enhanced Dipole Inversion

Jakob Meineke1, Fabian Wenzel1, Iain D. Wilkinson2, and Ulrich Katscher1

1Philips Research Europe, Hamburg, Germany, 2University of Sheffield, Sheffield, United Kingdom

Quantitative Susceptibility Mapping (QSM) is used to study the deep gray-matter nuclei of patients with Alzheimer’s Disease (AD) and healthy control subjects. QSM is performed using “Joint background-field removal and segmentation-Enhanced Dipole Inversion” (JEDI), which leverages the information from automated model-based segmentation and allows the compact single-step formulation of the ill-posed inversion problem of QSM. The tissue magnetic susceptibility shows a trend for increase in the amygdala and the putamen of AD patients as compared to healthy control subjects, in agreement with previous studies.

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