Abstract #4051

Quantitative Susceptibility Mapping in Alzheimer’s Disease using Joint background-field removal and segmentation-Enhanced Dipole Inversion

Jakob Meineke¹, Fabian Wenzel¹, Iain D. Wilkinson², and Ulrich Katscher¹

¹Philips Research Europe, Hamburg, Germany, ²University of Sheffield, Sheffield, United Kingdom

Quantitative Susceptibility Mapping (QSM) is used to study the deep gray-matter nuclei of patients with Alzheimer’s Disease (AD) and healthy control subjects. QSM is performed using “Joint background-field removal and segmentation-Enhanced Dipole Inversion” (JEDI), which leverages the information from automated model-based segmentation and allows the compact single-step formulation of the ill-posed inversion problem of QSM. The tissue magnetic susceptibility shows a trend for increase in the amygdala and the putamen of AD patients as compared to healthy control subjects, in agreement with previous studies.

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